Recently, the research team of Huang Haishan from the School of Laboratory Medicine (School of Life Sciences) published its research result with the title of "Oncogenic role of MIR516A in human bladder cancer was mediated by its attenuating PHLPP2 expression and BECN1-dependent autophagy” in Autophagy (TOP, Zone 1, IF = 11.059), a top international journal in the field of autophagy research.
Bladder cancer is one of the common malignant tumors, and its morbidity and mortality in China are on the rise. Huang Haishan’s team has been working on the exploration of new targets of malignant tumors and related molecular mechanisms. With rich research experience in related fields, the team has achieved fruitful results. The research team found that by regulating the expression of its downstream target gene PHLPP2, mir-516a regulates the expression of Beclin1 through the CUL4A-mediated ubiquitinated protein degradation pathway, inhibits the autophagic activity of bladder cancer cells, and ultimately promotes the proliferation of bladder cancer cells. The new miR-516a / PHLPP2 / CUL4A / Beclin1 pathway provides new insights into tumor-related autophagy research and also provides new strategies and targets for the prevention and treatment of bladder cancer.
This research was partially supported by the National Natural Science Foundation of China, Key Discipline of Zhejiang Province in Medical Technology (First Class, Category A), and Key Project of Science and Technology Innovation Team of Zhejiang Province. Dr. Honglei Jin of School of Laboratory Medicine (School of Life Sciences) is the first author and co-corresponding author of this article, graduate students Ma Jiugao, Xu Jiheng, and Li Hongyan are co-first authors, and Researcher Huang Haishan and Researcher Huang Xing from Zhejiang University are co-corresponding authors.